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Source arXiv Artificial Intelligence export.arxiv.org Analyst
July 10, 2026 ai_technology research

A safety-oriented hypothetico-deductive framework for AI-assisted differential diagnosis

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arXiv:2607.08038v1 Announce Type: new Abstract: Diagnostic error is a major threat to patient safety, yet current large language model (LLM) systems often treat diagnosis as a one-shot prediction task, lacking safeguards against missed high-risk alternatives or rigorous verification of their reasoning. Here, we present AegisDx, a safety-oriented framework for hypothetico-deductive clinical reasoning. AegisDx coordinates specialized LLM components through role-specific contracts, structured inter

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