SPIN Unprocessed October 15, 2026 ai_technology research
Do Vision CIL Methods Transfer to Protein? A Diagnostic Benchmark of Frozen Protein Encoders
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arXiv:2610.18879v1 Announce Type: new Abstract: Protein function annotation operates over an expanding label space, making class-incremental learning (CIL) a natural framework for incorporating newly discovered functions without full retraining. Yet existing CIL methods have been developed largely in vision and have not been systematically evaluated over frozen protein representations. We conduct a controlled benchmark of nine representative CIL methods across five sequence-, structure-, and seq
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